Trans platinum complexes design: One novel water soluble oxime derivative that contains aliphatic amines in trans configuration
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چکیده
منابع مشابه
Metal-organic anion receptors: trans-functionalised platinum complexes.
The anion complexation properties of a trans-functionalised platinum(II) complex have been studied revealing a high affinity for sulfate in solution and 3:2 receptor sulfate complex formation in the solid state with the anion bound in a pocket lined with 6 NH and 8 CH hydrogen-bond-donating groups.
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The reaction of cis-[PtCl₂(dmso)] with the salicylaldimine ligand, N-(2-hydroxybenzylidene)-2,6-di-isopropylaniline, LA in the presence of sodium acetate in methanol produced both cis- and trans-[PtClLA(dmso)], 1a and 1b. An analogous reaction for the less bulky ligand, N-(2-hydroxybenzylidene)aniline LB produced only cis-[PtClLB(dmso)], 2. The reactions of these dmso complexes with triphenylph...
متن کاملThermodynamic Parameters of Cis-Platin and Trans-Platin Complexes with Guanine in Water, A DFT Study
The binding energy and Thermodynamic Parameters of cis- Platinum Di Ammino Chlorine (cis-[Pt(NH3)2Cl]+) and trans- Platinum Di Ammino Chlorine (trans- [Pt(NH3)2Cl]+) complexes withGuanine has been studied by density functional theory (DFT) calculations in water. The bindingenergies (Ebin) of cis- and trans-[Pt(NH3)2ClG]+ are calculated to be 79.38 kcal/mol and 74.98kcal/mol, respectively. The b...
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In the title compound, [PtCl(4)(C(14)H(11)N)(2)], the Pt atom lies on an inversion center and has a distorted octa-hedral environment. The main geometric parameters are Pt-N = 1.960 (5) Å, and Pt-Cl = 2.3177 (12) and 2.3196 (12) Å. The N C bond is a typical triple bond [1.137 (7) Å]. The Pt-N C-C unit is almost linear, with Pt-N-C and N-C-C angles of 174.6 (4) and 177.1 (6)°, respectively.
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Methionine binding converts monofunctional platinum antitumor agents to trans configuration adducts in the reaction with DNA, which suggests the correlation of two classes of platinum complexes in the antitumor mechanism.
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ژورنال
عنوان ژورنال: Journal of Inorganic Biochemistry
سال: 2007
ISSN: 0162-0134
DOI: 10.1016/j.jinorgbio.2006.08.012